Adaptogens have long been associated with enhancing stamina and reducing mild fatigue. They encourage both physical work capacity and mental performance. Often referred to as tonics, they have mild and diverse effects on physiology, supporting immune, cardiovascular and endocrine functions. At the same time, they help the body to adapt to and cope with occasional stress, primarily by supporting the hypothalamic-pituitary-adrenal (HPA) axis. Panax ginseng promotes endurance and stamina, while also promoting cognitive, cardiovascular and immune function.Ashwagandha is recognized for supporting healthy stress responses and cognitive function. Rhodiola and eleuthero are traditionally associated with rejuvenating effects and the ability to promote endurance.